An egomaniacal genius and billionaire industrialist, Lex Luthor fights a neverending personal, public, and political battle against Superman.
Dourly dispirted Polka-Dot Man, the unfortunate alter-ego of Abner Krill, wears his rainbow-pustuled dermis with all the shame of an acne-riddled teen going stag to the prom. But when he fires his deadly polka-dots, he can turn even the smoothest of criminals into Swiss cheese, whether they're a fellow D-lister like Condiment King or an intergalactic threat like Starro the Conqueror.
One of the most feared and ruthless gangsters in Gotham City, Carmine "The Roman" Falcone isn't afraid to go up against both the Dark Knight and the GCPD.
Jade Nguyen's lethal martial arts skills and affinity for poisons have made her a dangerous and alluring enemy—and sometimes ally—to numerous heroes and villains.
A ruthless and conniving businessman, Simon Stagg of Stagg Enterprises has never let petty morality or empathy get in the way of closing a profitable deal.
Don't let Julian Day's obsession with holidays with fool you, the Calendar Man is one of Gotham City's most terrifying serial killers.